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MAGL-IN-222

MAGL Inhibitor

MAGL-IN-222 is a covalent inhibitor that targets monoacylglycerol lipase (MAGL) with an IC50 of 42.31 μM. By inhibiting MAGL, MAGL-IN-222 effectively reduces the degradation of 2-arachidonoylglycerol (2-AG), leading to increased intracellular levels of 2-AG. This mechanism has demonstrated potential in inhibiting proliferation and migration of MDA-MB-231 breast cancer cells, making it a valuable reagent for research in breast cancer and related pathological conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	877804-65-4
Applications	MAGL Inhibitor
Formula	C₂₂H₂₅N₃O₄S
Molecular Weight	427.52
SMILES	CC(/C(C(N1C2CCS(C2)(=O)=O)=O)=C/C3=CC=C(N(CC)CC)C=C3)=C(C#N)C1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.