Fig. 1 · Structure
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MAGLi 432
MAGL Inhibitor
MAGLi 432 is a potent and highly selective non-covalent inhibitor of monoacylglycerol lipase (MAGL). It demonstrates remarkable affinity for the MAGL active site, exhibiting IC50 values of 4.2 nM for the human enzyme and 3.1 nM for the mouse enzyme. This inhibitor is valuable for research focused on chronic inflammation, blood-brain barrier integrity, and various neurological disorders, including multiple sclerosis, Alzheimer's disease, and Parkinson's disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2361575-20-2 |
| Applications | MAGL Inhibitor |
| Formula | C22H24BrClN2O2 |
| Molecular Weight | 463.80 |
| SMILES | O=C(C1=CC=CC(OC)=C1Br)N2C[C@](CC[C@H](C3=CC=C(Cl)C=C3)C4)([H])N4CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.