Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker designed to facilitate targeted drug delivery in antibody-drug conjugates. The maleimide group enables covalent attachment to free thiols present on cysteine residues in proteins, while the hydrophilic PEG spacer enhances solubility and reduces immunogenicity. Upon internalization, the Val-Cit dipeptide is cleaved by cellular proteases, allowing for the efficient release of the therapeutic payload, aided by the PAB functional group. This linker is suitable for use in cancer research and therapeutic development.
Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker designed to facilitate targeted drug delivery in antibody-drug conjugates. The maleimide group enables covalent attachment to free thiols present on cysteine residues in proteins, while the hydrophilic PEG spacer enhances solubility and reduces immunogenicity. Upon internalization, the Val-Cit dipeptide is cleaved by cellular proteases, allowing for the efficient release of the therapeutic payload, aided by the PAB functional group. This linker is suitable for use in cancer research and therapeutic development.
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