Mal-amido-PEG3-C1-​NHS ester

Catalog No.: A43277
ADC linker
Mal-amido-PEG3-C1-NHS ester is a non-cleavable 3-unit polyethylene glycol (PEG) linker designed for antibody-drug conjugate (ADC) synthesis. This reactive NHS ester facilitates the conjugation of cytotoxic agents to antibodies, enabling targeted delivery for enhanced therapeutic efficacy. Its application is crucial in the development of ADCs aimed at improving treatment outcomes in various cancers.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMal-amido-PEG3-C1-NHS ester is a non-cleavable 3-unit polyethylene glycol (PEG) linker designed for antibody-drug conjugate (ADC) synthesis. This reactive NHS ester facilitates the conjugation of cytotoxic agents to antibodies, enabling targeted delivery for enhanced therapeutic efficacy. Its application is crucial in the development of ADCs aimed at improving treatment outcomes in various cancers.
Product Information
Catalog NumA43277
FormulaC19H25N3O10
Molecular Weight455.42
CAS Number2101206-45-3
SMILESO=C(ON1C(CCC1=O)=O)COCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O
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