Mal-PEG2-VCP-NB

Catalog No.: A42978
ADC Linker
Mal-PEG2-VCP-NB is a cleavable antibody-drug conjugate (ADC) linker featuring a Maleimide group, a polyethylene glycol (PEG) spacer of two units, and a valine-citrulline-p-nitrobenzyl (VCP-NB) moiety. This linker is designed to improve the delivery of cytotoxic agents specifically to target cells while minimizing off-target effects. Its application in ADC development supports research aimed at enhancing therapeutic efficacy in cancer treatment and advancing targeted drug delivery systems.
Grouped product items
Size Price Stock Qty
25mg
$310.00
In stock
50mg
$450.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMal-PEG2-VCP-NB is a cleavable antibody-drug conjugate (ADC) linker featuring a Maleimide group, a polyethylene glycol (PEG) spacer of two units, and a valine-citrulline-p-nitrobenzyl (VCP-NB) moiety. This linker is designed to improve the delivery of cytotoxic agents specifically to target cells while minimizing off-target effects. Its application in ADC development supports research aimed at enhancing therapeutic efficacy in cancer treatment and advancing targeted drug delivery systems.
Product Information
Catalog NumA42978
FormulaC36H45N7O13
Molecular Weight783.78
CAS Number2395887-69-9
SMILESO=C(OCC1=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCN2C(C=CC2=O)=O)=O)=O)=O)C=C1)OC3=CC=C([N+]([O-])=O)C=C3
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