Mal-PEG4-Val-Cit-PAB-OH is a cleavable polyethylene glycol (PEG) linker designed for the synthesis of antibody-drug conjugates (ADCs). This linker features a Val-Cit dipeptide sequence that permits selective release of the cytotoxic drug upon cellular uptake. Its application enhances the therapeutic index of ADCs by improving solubility and stability while facilitating effective drug delivery in targeted cancer therapies.
Mal-PEG4-Val-Cit-PAB-OH is a cleavable polyethylene glycol (PEG) linker designed for the synthesis of antibody-drug conjugates (ADCs). This linker features a Val-Cit dipeptide sequence that permits selective release of the cytotoxic drug upon cellular uptake. Its application enhances the therapeutic index of ADCs by improving solubility and stability while facilitating effective drug delivery in targeted cancer therapies.
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