Fig. 1 · Structure
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Mal-VC-PAB-DMEA-PNU-159682
Agent-linker Conjugate For ADC
Mal-VC-PAB-DMEA-PNU-159682 is an agent-linker conjugate designed for antibody-drug conjugate (ADC) applications, targeting topoisomerase II with the potent inhibitor PNU-159682. This compound features a lysosomally cleavable dipeptide, Mc-VC-PAB, which facilitates the selective release of the active drug within tumor cells, enhancing its antitumor efficacy. Mal-VC-PAB-DMEA-PNU-159682 is suitable for the synthesis of Anti-CD22-NMS249, enabling advanced research in targeted cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1178887-17-6 |
| Applications | Agent-linker Conjugate For ADC |
| Formula | C66H83N9O22 |
| Molecular Weight | 1354.41 |
| Synonyms | SET0568 |
| SMILES | OC1=C2C(C(C3=C(OC)C=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@H]5C[C@]6([H])N7[C@]([C@H](OCC7)OC)([H])O[C@]6([H])[C@@H](O5)C)=C1C[C@](O)(C4)C(COC(N(C)CCN(C)C(OCC8=CC=C(C=C8)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN9C(C=CC9=O)=O)=O)=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.