MANT-GppNHp is a competitive inhibitor of adenylate cyclase (AC) that serves as a fluorescently labeled GTP analogue. It specifically interacts with the hydrophobic pocket adjacent to the AC catalytic site through its MANT group, effectively obstructing the binding of ATP. This compound is valuable for investigating diseases characterized by elevated AC activity, such as cholera, and offers insights into cellular signaling pathways.
MANT-GppNHp is a competitive inhibitor of adenylate cyclase (AC) that serves as a fluorescently labeled GTP analogue. It specifically interacts with the hydrophobic pocket adjacent to the AC catalytic site through its MANT group, effectively obstructing the binding of ATP. This compound is valuable for investigating diseases characterized by elevated AC activity, such as cholera, and offers insights into cellular signaling pathways.
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