Margetuximab

Catalog No.: AT0027

Margetuximab is a chimeric anti-HER2 IgG1 monoclonal antibody engineered with an optimized Fc domain to enhance antibody-dependent cellular cytotoxicity (ADCC). With an EC₅₀ of 39.33 ng/mL, Margetuximab is used in the study of HER2-positive metastatic breast cancer and immune effector cell engagement.

Grouped product items
Size Price Stock Qty
1mg
$224.00
In stock
5mg
$544.00
In stock
10mg
$880.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

Loading distributor info...

Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description

Margetuximab is a chimeric anti-HER2 IgG1 monoclonal antibody engineered with an optimized Fc domain to enhance antibody-dependent cellular cytotoxicity (ADCC). With an EC₅₀ of 39.33 ng/mL, Margetuximab is used in the study of HER2-positive metastatic breast cancer and immune effector cell engagement.

Targets EC50: 39.33 ng/mL (HER2)
Product Information
Catalog NumAT0027
Molecular Weight146100
CAS Number1350624-75-7
IsotypeHuman IgG1 kappa, Isotype Control
SpeciesChimeric
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2

Frequently Asked Questions
What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.