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MB076

Boronic Acid/ADC Variants Inbihitor

MB076 is a heterocyclic triazole that acts as an inhibitor of Class C Acinetobacter-derived cephalosporinases (ADCs), displaying improved plasma stability. This compound efficiently inhibits seven β-lactamase variants with Ki values less than 1 μM, offering potential in combating antibiotic resistance. Additionally, MB076 demonstrates synergistic effects when combined with various cephalosporins, effectively restoring susceptibility in pBCSK(-) strains. This makes it a valuable reagent for research related to antibiotic resistance mechanisms and β-lactamase inhibition.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2832966-95-5
Applications	Boronic Acid/ADC Variants Inbihitor
Formula	C₉H₁₂BN₇O₅S₂
Molecular Weight	373.18
SMILES	NC1=NN=C(SCC(N[C@H](B(O)O)CN2C=C(C(O)=O)N=N2)=O)S1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.