Fig. 1 · Structure

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Mc-Asn-Asn

ADC Linker

Mc-Asn-Asn is a legumain-cleavable linker designed for use in antibody-drug conjugates (ADCs), facilitating the conjugation of antibodies to cytotoxic agents. This compound is instrumental in the synthesis of ADCs, enabling targeted delivery of therapeutic payloads to enhance antitumor efficacy while minimizing off-target effects. Its selective cleavage by legumain allows for controlled release of the active drug, making it a valuable tool in cancer research and therapy development.

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Specifications

Manufacturer Adooq Bioscience
CAS Number 3059867-76-1
Applications ADC Linker
Formula C18H25N5O8
Molecular Weight 439.42
SMILES
O=C(C=CC1=O)N1CCCCCC(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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