Fig. 1 · Structure
Documents & Downloads
MC-GGFG-AM-(10Me-11F-Camptothecin)
Linker-Payload
MC-GGFG-AM-(10Me-11F-Camptothecin) is a specialized linker-payload conjugate designed for the synthesis of ZW251, an antibody-drug conjugate (ADC) that targets human glypican-3 (GPC3). This compound incorporates a humanized IgG1 antibody attached to a camptothecin-based topoisomerase I inhibitor, ZD06519, via a cleavable maleimide-GGFG-AM linker. ZW251 exhibits a strong affinity for GPC3, facilitating rapid internalization in GPC3-expressing hepatocellular carcinoma (HCC) cell lines and demonstrating potential for bystander-mediated cytotoxic effects on GPC3-negative cancer cells. This product is invaluable for research focused on targeted cancer therapies and ADC development.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2873460-70-7 |
| Applications | Linker-Payload |
| Formula | C51H56FN9O14 |
| Molecular Weight | 1038.04 |
| SMILES | FC1=C(C)C=C2C(CNC(OCCOCNC(CNC([C@H](CC3=CC=CC=C3)NC(CNC(CNC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)=O)=C5C(C(N6C5)=CC([C@@](O)(CC)C(OC7)=O)=C7C6=O)=NC2=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.