MC-Gly-Gly-Phe-Gly-cyclopropylacetic acid

Catalog No.: A43300
ADC Linker
MC-Gly-Gly-Phe-Gly-cyclopropylacetic acid is a cleavable linker specifically designed for the assembly of antibody-drug conjugates (ADCs). This compound facilitates the stable attachment of cytotoxic agents to antibodies, enabling targeted delivery and enhanced therapeutic efficacy. Its unique structure allows for selective cleavage under physiological conditions, resulting in the release of the drug at the desired site of action. This makes it a valuable tool in the development of innovative cancer therapies.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMC-Gly-Gly-Phe-Gly-cyclopropylacetic acid is a cleavable linker specifically designed for the assembly of antibody-drug conjugates (ADCs). This compound facilitates the stable attachment of cytotoxic agents to antibodies, enabling targeted delivery and enhanced therapeutic efficacy. Its unique structure allows for selective cleavage under physiological conditions, resulting in the release of the drug at the desired site of action. This makes it a valuable tool in the development of innovative cancer therapies.
Product Information
Catalog NumA43300
FormulaC31H40N6O10
Molecular Weight656.68
CAS Number2626930-80-9
SMILESO=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCO[C@H](C3CC3)C(O)=O)=O)=O)=O)=O)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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