MC-Val-Ala-NHS ester is a cleavable antibody-drug conjugate (ADC) linker that features both a malimide group and an NHS ester group. It facilitates the specific cleavage of Val-Ala linkers by Cathepsin B while the maleimide moiety allows for selective conjugation to thiol groups. The NHS ester efficiently forms stable covalent bonds with amines, such as lysine side chains, under neutral or slightly basic conditions. This reagent is ideal for applications in ADC development, enabling targeted delivery of therapeutic agents.
MC-Val-Ala-NHS ester is a cleavable antibody-drug conjugate (ADC) linker that features both a malimide group and an NHS ester group. It facilitates the specific cleavage of Val-Ala linkers by Cathepsin B while the maleimide moiety allows for selective conjugation to thiol groups. The NHS ester efficiently forms stable covalent bonds with amines, such as lysine side chains, under neutral or slightly basic conditions. This reagent is ideal for applications in ADC development, enabling targeted delivery of therapeutic agents.
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