MC-Val-Cit-PAB-NH-C2-NH-Boc

Catalog No.: A43279
ADC Linker
MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This reagent facilitates targeted delivery of cytotoxic agents by enabling selective release upon cleavage in the tumor microenvironment. Its application in ADC development supports research in cancer therapeutics and targeted drug delivery mechanisms.
Grouped product items
Size Price Stock Qty
5mg
$320.00
In stock
10mg
$525.00
In stock
25mg
$1,050.00
In stock
50mg
$1,640.00
In stock
100mg
$2,560.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This reagent facilitates targeted delivery of cytotoxic agents by enabling selective release upon cleavage in the tumor microenvironment. Its application in ADC development supports research in cancer therapeutics and targeted drug delivery mechanisms.
Product Information
Catalog NumA43279
FormulaC36H54N8O10
Molecular Weight758.86
CAS Number1616727-22-0
SMILESCC(C)(C)OC(NCCNC(OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)=O)=O
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