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MC-Val-D-Cit-PAB-PNP

Catalog No.: A42997
ADC Linker
MC-Val-D-Cit-PAB-PNP is a cleavable peptide linker designed for use in antibody-drug conjugates (ADCs). This linkage incorporates a maleimidocaproyl (Mc) group for efficient conjugation to antibodies, paired with a p-nitrophenol (PNP) moiety that facilitates attachment to antitumor agents. Its applications include enhancing targeted delivery of therapeutics and improving efficacy in cancer treatment research.
MC-Val-D-Cit-PAB-PNP 1350456-66-4 ADC Linker
Grouped product items
Size Price Stock Qty
25mg
$260.00
In stock
50mg
$410.00
In stock
100mg
$640.00
In stock
Bulk Size
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMC-Val-D-Cit-PAB-PNP is a cleavable peptide linker designed for use in antibody-drug conjugates (ADCs). This linkage incorporates a maleimidocaproyl (Mc) group for efficient conjugation to antibodies, paired with a p-nitrophenol (PNP) moiety that facilitates attachment to antitumor agents. Its applications include enhancing targeted delivery of therapeutics and improving efficacy in cancer treatment research.
Product Information
Catalog NumA42997
FormulaC35H43N7O11
Molecular Weight737.76
CAS Number1350456-66-4
SMILESO=C(NC(C=C1)=CC=C1COC(OC(C=C2)=CC=C2[N+]([O-])=O)=O)[C@@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN(C3=O)C(C=C3)=O)=O)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

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    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

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    C2

    V2

Antibody-drug Conjugates (ADC) > ADC Linker