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Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2

MMP Substrate

Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is a highly selective substrate for matrix metalloproteinase 12 (MMP12), exhibiting a kcat/Km value of 1.85 x 10^5 M^-1s^-1. This compound shows limited activity against other matrix metalloproteinases, with notable kcat/Km values of 0.53 x 10^5 M^-1s^-1 for MMP13 and 0.33 x 10^5 M^-1s^-1 for MMP9. This selective profile makes it a useful tool for studying the role of MMP12 in biological processes and for potential therapeutic applications targeting MMP-related pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Substrate
CAS Number	891198-38-2
Applications	MMP Substrate
Formula	C₅₃H₇₀N₁₂O₂₀
Molecular Weight	1195.19

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.