MCH (human, mouse, rat) is a cyclic neuropeptide that functions as an endogenous ligand for the melanin-concentrating hormone receptor (MCH-R). It exhibits high binding affinity with IC50 values of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively, and operational EC50 values of 3.9 nM and 88.7 nM. MCH plays a crucial role in regulating appetite as an orexigenic signal and is instrumental in maintaining energy homeostasis and sleep-wake cycles. This reagent is essential for research into obesity, sleep-related disorders, and related metabolic conditions.
MCH (human, mouse, rat) is a cyclic neuropeptide that functions as an endogenous ligand for the melanin-concentrating hormone receptor (MCH-R). It exhibits high binding affinity with IC50 values of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively, and operational EC50 values of 3.9 nM and 88.7 nM. MCH plays a crucial role in regulating appetite as an orexigenic signal and is instrumental in maintaining energy homeostasis and sleep-wake cycles. This reagent is essential for research into obesity, sleep-related disorders, and related metabolic conditions.
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