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MD102

TG2 Inhibitor

MD102 is a potent transglutaminase 2 (TG2) inhibitor with an IC50 value of 0.35 μM. By inhibiting TG2, MD102 enhances the stabilization of p53 and leads to a reduction in phosphorylated AKT and mTOR signaling pathways, ultimately promoting tumor cell apoptosis. This compound is valuable for research into cancer biology and therapeutic strategies targeting TG2-related pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2755794-94-4
Applications	TG2 Inhibitor
Formula	C₁₃H₄BrCl₂FN₂O₂
Molecular Weight	389.99
SMILES	BrC1=CC=C(C2=NC(C(C(Cl)=C(Cl)C3=O)=O)=C3N2)C=C1F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.