MD2-TLR4-IN-1

Catalog No.: A18452

MD2-TLR4 inhibitor

MD2-TLR4-IN-1

MD2-TLR4-IN-1 Chemical Structure

CAS NO. 2249801-12-3

MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively.

Availability: In stock

Package Price Qty
1 mg
$320.00
5 mg
$960.00
10 mg
$1,600.00
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Biological Activity

MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.74 mL 118.69 mL 237.37 mL
0.5 mM 4.75 mL 23.74 mL 47.47 mL
1 mM 2.37 mL 11.87 mL 23.74 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

*The above data is based on the productmolecular weight 421.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18452
Actions Inhibitor
M. Wt 421.28
Formula C22H14Cl2N4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2249801-12-3
SMILES ClC1=C(C(NC2=CC(C(C3=CC=C(NC=C4)C4=C3)=NN5)=C5C=C2)=O)C(Cl)=CC=C1

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