mDPR(Boc)-Val-Cit-PAB

Catalog No.: A43207
ADC linker
mDPR(Boc)-Val-Cit-PAB is a cleavable linker specifically designed for antibody-drug conjugates (ADCs). It features a unique mechanism that facilitates the release of cytotoxic agents upon cellular internalization. This compound plays a critical role in enhancing the therapeutic efficacy of ADCs by improving selective drug delivery to targeted cancer cells. Its utility makes it a valuable reagent in cancer research and the development of targeted therapies.
Grouped product items
Size Stock
5mg
10mg
50mg
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Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionmDPR(Boc)-Val-Cit-PAB is a cleavable linker specifically designed for antibody-drug conjugates (ADCs). It features a unique mechanism that facilitates the release of cytotoxic agents upon cellular internalization. This compound plays a critical role in enhancing the therapeutic efficacy of ADCs by improving selective drug delivery to targeted cancer cells. Its utility makes it a valuable reagent in cancer research and the development of targeted therapies.
Product Information
Catalog NumA43207
FormulaC30H43N7O9
Molecular Weight645.70
CAS Number2281797-55-3
SMILESO=C([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](N1C(C=CC1=O)=O)CNC(OC(C)(C)C)=O)=O)=O)NC2=CC=C(CO)C=C2
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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