Fig. 1 · Structure
Documents & Downloads
MEDS433
hDHODH Inhibitor
MEDS433 is a selective inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibiting an IC50 of 1.2 nM. This compound demonstrates significant antiviral activity against respiratory syncytial virus (RSV) strains A and B, operating within the nanomolar range. MEDS433 enhances the expression of antiviral proteins derived from interferon-stimulated genes (ISGs), effectively diminishing RSV replication. This makes MEDS433 a valuable tool for research on antiviral therapies and the mechanisms of viral replication inhibition.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2241027-61-0 |
| Applications | hDHODH Inhibitor |
| Formula | C20H11F4N3O2 |
| Molecular Weight | 401.31 |
| SMILES | O=C(C1=C2C=CC=CN2N=C1O)NC3=C(F)C(F)=C(C4=CC=CC=C4)C(F)=C3F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.