Fig. 1 · Structure
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Melflufen
Alkylating Agent
Melflufen (Melphalan flufenamide) functions as an alkylating agent with significant antitumor activity against multiple myeloma (MM) cells. This dipeptide prodrug of Melphalan induces irreversible DNA damage, leading to cytotoxic effects in MM cells. Additionally, Melflufen exhibits the ability to inhibit angiogenesis, making it a valuable tool for research into cancer therapies and treatment strategies for hematological malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 380449-51-4 |
| Applications | Alkylating Agent |
| Formula | C24H30Cl2FN3O3 |
| Molecular Weight | 498.42 |
| Synonyms | Melphalan flufenamide |
| SMILES | N(CCCl)(CCCl)C1=CC=C(C[C@@H](C(N[C@@H](CC2=CC=C(F)C=C2)C(OCC)=O)=O)N)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.