Fig. 1 · Structure
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Men 10376
Tachykinin NK-2 Receptor Antagonist
Men 10376 is a selective tachykinin NK-2 receptor antagonist that exhibits a Ki value of 4.4 μM for the rat small intestine NK-2 receptor. This compound demonstrates significant inhibition of NK-2 receptor-mediated biological activities, making it a valuable tool for research into neurokinin signaling pathways. It is applicable in studies focused on gastrointestinal motility, pain modulation, and other physiological processes mediated by tachykinins.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 135306-85-3 |
| Applications | Tachykinin NK-2 Receptor Antagonist |
| Formula | C57H68N12O10 |
| Molecular Weight | 1081.22 |
| Synonyms | Neurokinin-2 receptor antagonist |
| SMILES | C([C@H](C(N[C@H](CC=1C=2C(NC1)=CC=CC2)C(N[C@@H](CCCCN)C(N)=O)=O)=O)NC([C@@H](NC([C@@H](CC=3C=4C(NC3)=CC=CC4)NC([C@H](CC5=CC=C(O)C=C5)NC([C@H](CC(O)=O)N)=O)=O)=O)C(C)C)=O)C=6C=7C(NC6)=CC=CC7 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.