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Merafloxacin

Merafloxacin, also known as CI 934, is a fluoroquinolone antibacterial, which was also identified as a -1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on -1 PRF of other beta coronaviruses. Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting -1 PRF as an effective antiviral strategy for SARS-CoV-2.

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Biological Activity

Cellular Effect

Cell Line	Activity	Value	Description	Reference
MCF7	IC50	33.5 μM	Inhibition of programmed -1 ribosomal frameshifting in human MCF7 cells harboring pCherryGFP-CoV2-WT plasmid assessed as inhibition of GFP expression incubated for 30 mins by fluorescence microscopic analysis	[PMID: 37312842]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	91188-00-0
Formula	C₁₉H₂₃F₂N₃O
Molecular Weight	379.4078
Synonyms	CI 934
SMILES	O=C(C1=CN(CC)C2=C(C=C(F)C(N3CC(CNCC)CC3)=C2F)C1=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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Merafloxacin

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DMSO Solution

Merafloxacin 1 mg