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Meso-tetraphenylchlorin

Photosensitizer

Meso-tetraphenylchlorin (TPCS2a) is a photosensitizer with notable applications in photodynamic therapy, particularly in targeting cancer cells. Due to its poor water solubility, TPCS2a is often formulated as nanoparticles (TPCS2a@NPs) using a polylactic-co-polyethylene glycol acid (PLGA) core. These nanoparticles can be further enhanced by coating them with mesenchymal stem cell-derived plasma membranes (mMSC-TPCS2a@NPs), which improve blood circulation time and tumor targeting efficiency. Compared to uncoated nanoparticles, mMSC-TPCS2a@NPs exhibit reduced macrophage uptake while demonstrating effective accumulation in breast cancer cell lines MCF7 and MDA-MB-231, with minimal uptake in normal breast epithelial cells.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2669-65-0
Applications	Photosensitizer
Formula	C₄₄H₃₄N₄
Molecular Weight	618.77
Synonyms	Fimaporfin free base
SMILES	C1(/C(C(N2)=CC=C2/C(C3=CC=CC=C3)=C4CCC5=N\4)=C6C=CC(/C(C7=CC=CC=C7)=C(N/8)\CCC8=C5\C9=CC=CC=C9)=N/6)=CC=CC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.