Fig. 1 · Structure
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Metallo-β-lactamase-IN-3
MBL Inhibitor
Metallo-β-lactamase-IN-3 is a potent inhibitor of metallo-β-lactamases (MBLs), specifically targeting VIM-1 and NDM-1 with IC50 values of 0.6 and 1.0 μM, respectively. This compound exhibits selectivity, as it does not inhibit IMP-7. Metallo-β-lactamase-IN-3 is a valuable tool for research in antibiotic resistance, providing insights into MBL inhibition and potential therapeutic strategies against resistant bacterial strains.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 128294-71-3 |
| Applications | MBL Inhibitor |
| Formula | C10H11NO3S |
| Molecular Weight | 225.26 |
| SMILES | O=C(O)C1=CC=C(NC(CCS)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.