Fig. 1 · Structure
Documents & Downloads
Methotrexate-γ-aspartate
Dihydrofolate Reductase Inhibitor
Methotrexate-γ-aspartate is a potent dihydrofolate reductase inhibitor, exhibiting enhanced resistance to enzymatic cleavage compared to methotrexate-γ-glutamate. This compound is utilized in antibody-targeted liposome formulations, making it a valuable tool for research in leukemia treatment. Its unique properties support its role in studying folate metabolism and chemoresistance in cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 64801-58-7 |
| Applications | Dihydrofolate Reductase Inhibitor |
| Formula | C24H27N9O8 |
| Molecular Weight | 569.53 |
| SMILES | NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CC(O)=O)=O)=O)C)C=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.