Methotrexate hydrate

Catalog No.: A46351
Biochemical Assay Reagent
Methotrexate hydrate is a potent inhibitor of dihydrofolate reductase, targeting folate metabolism to disrupt DNA synthesis and cellular proliferation. This reagent is widely utilized in biochemical assays, particularly in cancer research and the treatment of autoimmune disorders, to examine cell growth, division, and response to therapy. Its mechanism of action provides a critical tool for investigating cellular processes and therapeutic efficacy in various disease models.
Grouped product items
Size Price Stock Qty
50mg
$20.00
In stock
100mg
$25.00
In stock
250mg
$30.00
In stock
500mg
$35.00
In stock
1g
$40.00
In stock
5g
$50.00
In stock
10g
$80.00
In stock
25g
$165.00
In stock
50g
$245.00
In stock
100g
$390.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMethotrexate hydrate is a potent inhibitor of dihydrofolate reductase, targeting folate metabolism to disrupt DNA synthesis and cellular proliferation. This reagent is widely utilized in biochemical assays, particularly in cancer research and the treatment of autoimmune disorders, to examine cell growth, division, and response to therapy. Its mechanism of action provides a critical tool for investigating cellular processes and therapeutic efficacy in various disease models.
Product Information
Catalog NumA46351
FormulaC20H22N8O5.xH2O
Molecular Weight472.462
CAS Number133073-73-1
SMILESNC1=NC(N)=C2C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=N1.O.[x]
SynonymsAmethopterin hydrate; CL14377 hydrate; WR19039 hydrate
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2