MFZ 10-7 hydrochloride is a potent and selective negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGluR5), exhibiting a Ki of 0.67 nM for rat mGluR5. This compound serves as a valuable tool in neurological research, particularly for studies related to synaptic transmission and potential therapeutic approaches for neurodegenerative diseases. Furthermore, MFZ 10-7 hydrochloride features an alkyne group, enabling its use in click chemistry applications, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-bearing molecules.
MFZ 10-7 hydrochloride is a potent and selective negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGluR5), exhibiting a Ki of 0.67 nM for rat mGluR5. This compound serves as a valuable tool in neurological research, particularly for studies related to synaptic transmission and potential therapeutic approaches for neurodegenerative diseases. Furthermore, MFZ 10-7 hydrochloride features an alkyne group, enabling its use in click chemistry applications, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-bearing molecules.
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