Fig. 1 · Structure
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MFZ 10-7
mGluR5 Antagonist
MFZ 10-7 is a highly potent and selective negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), exhibiting a Ki of 0.67 nM for rat mGluR5. This compound serves as an essential tool for investigating the pharmacological modulation of mGluR5 activity, particularly in studies of psychiatric and neurodegenerative disorders. Additionally, MFZ 10-7 contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it suitable for applications in click chemistry.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1224431-15-5 |
| Applications | mGluR5 Antagonist |
| Formula | C15H9FN2 |
| Molecular Weight | 236.24 |
| SMILES | N#CC1=CC(C#CC2=NC(C)=CC=C2)=CC(F)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.