Fig. 1 · Structure
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MGL-IN-1
MAGL Inhibitor
MGL-IN-1 is a potent and selective irreversible inhibitor of monoacylglycerol lipase (MAGL), exhibiting a β-lactam structure. This compound has demonstrated the ability to alleviate symptoms in a multiple sclerosis model and produces analgesic effects in an acute inflammatory pain model, both in vivo. Additionally, MGL-IN-1 possesses high membrane permeability, facilitating effective brain penetration for central nervous system research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1881244-28-5 |
| Applications | MAGL Inhibitor |
| Formula | C24H22FN5O4 |
| Molecular Weight | 463.46 |
| SMILES | O=C1N(C(CC2)CCN2C(N3C=NC=N3)=O)[C@@](C4=CC=C5C(OCO5)=C4)([H])[C@@]1([H])C(C=C6)=CC=C6F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.