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MH44

N7-MTase Inhibitor

MH44 is a selective inhibitor of the SARS-CoV-2 nsp14 N7-methyltransferase (N7-MTase), exhibiting an IC50 value of 19 nM. This compound demonstrates moderate antiviral effects against SARS-CoV-2 in A549-hACE2 cells, with noted cytotoxicity at elevated concentrations. MH44 serves as a valuable tool in research focused on combating SARS-CoV-2.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2766190-68-3
Applications	N7-MTase Inhibitor
Formula	C₂₀H₂₃N₇O₆S
Molecular Weight	489.50
SMILES	O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CN(S(=O)(C4=CC(C#N)=C(OC)C=C4)=O)CC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.