MK-0536 is a potent inhibitor of HIV-1 integrase, demonstrating significant efficacy in suppressing the replication of wild-type viruses. This compound retains antiviral activity against several drug-resistant mutants, including Y143R and N155H, while exhibiting no cytotoxic effects on uninfected cells. MK-0536 operates by selectively blocking the strand transfer reaction of integrase through magnesium ion chelation at the active site, as well as interactions with viral DNA and integrase residues. This reagent is valuable for investigating the mechanisms underlying HIV infection and resistance.
MK-0536 is a potent inhibitor of HIV-1 integrase, demonstrating significant efficacy in suppressing the replication of wild-type viruses. This compound retains antiviral activity against several drug-resistant mutants, including Y143R and N155H, while exhibiting no cytotoxic effects on uninfected cells. MK-0536 operates by selectively blocking the strand transfer reaction of integrase through magnesium ion chelation at the active site, as well as interactions with viral DNA and integrase residues. This reagent is valuable for investigating the mechanisms underlying HIV infection and resistance.
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