Fig. 1 · Structure
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MK-3402
Cat. No.
A48150
CAS
2058151-78-1
Metallo-β-lactamase Inhibitor
MK-3402 is a potent metallo-β-lactamase inhibitor that exhibits IC50 values of 0.53 nM, 0.25 nM, and 0.169 nM against enzymes IMP-1, NDM-1, and VIM-1, respectively. This compound enhances the efficacy of beta-lactam antibiotics and is valuable in bacterial research, particularly in studies focused on combating antibiotic resistance. MK-3402's strong inhibitory properties make it a critical tool for investigating metallo-β-lactamase-mediated resistance mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2058151-78-1 |
| Applications | Metallo-β-lactamase Inhibitor |
| Formula | C15H19N9O5S2 |
| Molecular Weight | 469.50 |
| SMILES | NS(=O)(C1=C(C2=NN=NN2)C(C3=CN=C(N)C=C3)=CC=C1S(NC[C@H](O)CN)(=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.