Fig. 1 · Structure
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MK-4882
HCV Inhibitor
MK-4882 is an HCV NS5A inhibitor that demonstrates efficacy in reducing viral load in chimpanzee models of HCV infection. However, the compound has shown susceptibility to viral breakthrough, highlighting the need for more potent alternatives targeting a broader range of genotypes and addressing NS5A resistance mutations. Its application in research facilitates the understanding of HCV resistance mechanisms and the design of improved therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1246470-32-5 |
| Applications | HCV Inhibitor |
| Formula | C42H50N8O7 |
| Molecular Weight | 778.90 |
| SMILES | O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C2=NC=C(N2)C3=CC=C(C=C3)C4=CC5=CC(C6=CN=C(N6)[C@H]7N(CCC7)C([C@H](C(C)C)NC(OC)=O)=O)=CC=C5O4)=O)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.