Fig. 1 · Structure
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MK-8325 dihydrochloride
HCV NS5A Inhibitor
MK-8325 dihydrochloride is an inhibitor of the Hepatitis C Virus (HCV) NS5A protein, which plays a critical role in viral replication and assembly. This compound demonstrates effective oral bioactivity, making it a valuable tool in HCV research. Additionally, MK-8325 shows minimal inhibition of the human Ether-a-go-go Related Gene (hERG) at a concentration of 30 mM, indicating a potentially favorable safety profile for further studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1334314-19-0 |
| Applications | HCV NS5A Inhibitor |
| Formula | C43H54Cl2F2N8O6Si |
| Molecular Weight | 915.93 |
| SMILES | O=C([C@H](C(C)C)NC(OC)=O)N1C[Si](C[C@H]1C2=NC3=CC=C4C(C=CC(C5=CC=C(C6=CN=C([C@@H]7CC(CN7C([C@H](C(C)C)NC(OC)=O)=O)(F)F)N6)C=C5)=C4)=C3N2)(C)C.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.