MK-8353 (SCH900353)

Catalog No.: A16838

ERK inhibitor

MK-8353 (SCH900353)

MK-8353 (SCH900353) Chemical Structure

CAS NO. 1184173-73-6

MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay).

Availability: In stock

Package Price Qty
2 mg
$120.00
5 mg
$158.00
10 mg
$269.00
50 mg
$790.00
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Biological Activity

MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay).
In vitro DMSO 45 mg/mL (65.04 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.45 mL 72.27 mL 144.54 mL
0.5 mM 2.89 mL 14.45 mL 28.91 mL
1 mM 1.45 mL 7.23 mL 14.45 mL
5 mM 0.29 mL 1.45 mL 2.89 mL

*The above data is based on the productmolecular weight 691.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16838
Actions Inhibitor
CAS No. 1184173-73-6
Formula C37H41N9O3S
M. Wt 691.84
Purity >98%
Synonyms MK8353, MK 8353, SCH 900353, SCH-900353
SMILES O=C(CN1CC[[email protected]@](SC)(C(NC2=CC=C(NN=C3C4=CC=C(OC(C)C)N=C4)C3=C2)=O)C1)N5CCC(C6=CC=C(C7=NN(C)C=N7)C=C6)=CC5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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