MK-8353 (SCH900353)

Catalog No.: A16838

ERK inhibitor

MK-8353 (SCH900353) Chemical Structure

CAS NO. 1184173-73-6

MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay).

Availability: In stock

Package Price Qty
2 mg
$120.00
5 mg
$220.00
10 mg
$400.00
50 mg
$1,600.00

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Biological Activity

MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.45 mL 72.27 mL 144.54 mL
0.5 mM 2.89 mL 14.45 mL 28.91 mL
1 mM 1.45 mL 7.23 mL 14.45 mL
5 mM 0.29 mL 1.45 mL 2.89 mL

*The above data is based on the productmolecular weight 691.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16838
Actions Inhibitor
M. Wt 691.84
Formula C37H41N9O3S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1184173-73-6
Synonyms MK8353, MK 8353, SCH 900353, SCH-900353
SMILES O=C(CN1CC[[email protected]@](SC)(C(NC2=CC=C(NN=C3C4=CC=C(OC(C)C)N=C4)C3=C2)=O)C1)N5CCC(C6=CC=C(C7=NN(C)C=N7)C=C6)=CC5

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