Signaling Pathway
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| Discription | MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay). | ||
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| Catalog Num | A16838 |
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| Formula | C37H41N9O3S |
| Molecular Weight | 691.84 |
| CAS Number | 1184173-73-6 |
| SMILES | O=C(CN1CC[C@@](SC)(C(NC2=CC=C(NN=C3C4=CC=C(OC(C)C)N=C4)C3=C2)=O)C1)N5CCC(C6=CC=C(C7=NN(C)C=N7)C=C6)=CC5 |
| Synonyms | MK8353, MK 8353, SCH 900353, SCH-900353 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 45 mg/mL (65.04 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.45 mL | 72.27 mL | 144.54 mL |
| 0.5 mM | 2.89 mL | 14.45 mL | 28.91 mL |
| 1 mM | 1.45 mL | 7.23 mL | 14.45 mL |
| 5 mM | 0.29 mL | 1.45 mL | 2.89 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
