Fig. 1 · Structure
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MKI-1
MASTL Inhibitor
MKI-1 is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 of 9.9 μM. This compound demonstrates significant antitumor properties and enhances radiosensitivity in breast cancer through the activation of protein phosphatase 2A (PP2A). MKI-1 is particularly valuable in cancer research for its potential to modulate key signaling pathways involved in tumor progression and treatment response.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1190277-80-5 |
| Applications | MASTL Inhibitor |
| Formula | C18H14N4O |
| Molecular Weight | 302.33 |
| Synonyms | MASTL Kinase Inhibitor-1 |
| SMILES | O=C(NC1=NC2=CC=CC=C2N1)C3=CC=CC(N4C=CC=C4)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.