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MKI-3

MASTL Inhibitor

MKI-3 is a selective inhibitor of microtubule-associated serine/threonine kinase-like (MASTL) with an IC50 of 5.72 nM and a Kd of 1.89 nM. By disrupting the MASTL-ENSA-Aurora A signaling pathway, MKI-3 induces chromosomal instability, mitotic catastrophe, and apoptosis in cancer cells. This compound is particularly relevant for research investigating triple-negative breast cancer and may provide insights into novel therapeutic strategies targeting MASTL-related pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3084702-28-0
Applications	MASTL Inhibitor
Formula	C₂₁H₁₉N₇O
Molecular Weight	385.42
SMILES	O=C(C1=CC=C(NC2=NC3=CC=CC=C3C(NC4=NNC(C5CC5)=C4)=N2)C=C1)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.