Fig. 1 · Structure
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ML-226
MAGL Inhibitor
ML-226 is a potent inhibitor of the alpha/beta hydrolase domain-containing protein 11 (ABHD11), demonstrating in vitro and in situ inhibition with IC50 values of 15 nM and 0.68 nM, respectively. This compound is valuable for studying the role of ABHD11 in lipid metabolism and may have applications in modulating related biological pathways. ML-226 is particularly useful in research focused on metabolic disorders and neurodegenerative diseases associated with altered lipid homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2055172-43-3 |
| Applications | MAGL Inhibitor |
| Formula | C23H26N4O2 |
| Molecular Weight | 390.48 |
| SMILES | O=C(N1C(CC)CCCC1)N2N=CC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.