ML216

Catalog No.: A21754

BLM helicase inhibitor

ML216

ML216 Chemical Structure

CAS NO. 1430213-30-1

ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 μM and 0.97 μM for BLMfull-length and BLM636-1298, respectively.

Availability: In stock

Package Price Qty
5 mg
$59.00
10 mg
$102.00
50 mg
$304.00
100 mg
$607.00
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Biological Activity

ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 μM and 0.97 μM for BLMfull-length and BLM636-1298, respectively.
In vitro DMSO 33 mg/mL (86.09 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.09 mL 130.44 mL 260.88 mL
0.5 mM 5.22 mL 26.09 mL 52.18 mL
1 mM 2.61 mL 13.04 mL 26.09 mL
5 mM 0.52 mL 2.61 mL 5.22 mL

*The above data is based on the productmolecular weight 383.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21754
Actions Inhibitor
CAS No. 1430213-30-1
Formula C15H9F4N5OS
M. Wt 383.32
Purity >98%
Synonyms CID-49852229, CID49852229, CID 49852229; ML-216, ML 216
SMILES O=C(NC1=CC=C(F)C(C(F)(F)F)=C1)NC2=NN=C(S2)C3=CC=NC=C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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