ML351 is a potent inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 of 200 nM, demonstrating exceptional selectivity with over 250-fold preference compared to related isozymes such as 5-LOX, platelet 12-LOX, and 15-LOX-2, as well as ovine COX-1 and human COX-2. This compound has shown significant biological activity in preventing dysglycemia and reducing β-cell oxidative stress in a nonobese diabetic mouse model of Type 1 Diabetes. ML351 is useful in studying the role of 15-LOX-1 in metabolic diseases and may have implications for therapeutic strategies targeting oxidative stress in diabetes.
ML351 is a potent inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 of 200 nM, demonstrating exceptional selectivity with over 250-fold preference compared to related isozymes such as 5-LOX, platelet 12-LOX, and 15-LOX-2, as well as ovine COX-1 and human COX-2. This compound has shown significant biological activity in preventing dysglycemia and reducing β-cell oxidative stress in a nonobese diabetic mouse model of Type 1 Diabetes. ML351 is useful in studying the role of 15-LOX-1 in metabolic diseases and may have implications for therapeutic strategies targeting oxidative stress in diabetes.
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