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ML901

Antimalarial Agent

ML901 is an antimalarial agent that selectively inhibits the tyrosine tRNA synthetase of Plasmodium falciparum (PfYRS), demonstrating an IC50 value of 2 nM. This compound exhibits potent life-cycle killing activity in malaria mouse models, making it a valuable tool for studying malaria parasite infection and potential therapeutic interventions. Researchers can employ ML901 to explore mechanisms of malaria pathogenesis and evaluate new treatment strategies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2226228-02-8
Applications	Antimalarial Agent
Formula	C₁₁H₁₄F₂N₆O₇S
Molecular Weight	412.33
SMILES	O[C@@H]1[C@H](O)[C@@H](COS(N)(=O)=O)O[C@H]1N2C3=NC=NC(N)=C3C(OC(F)F)=N2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.