Fig. 1 · Structure
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MM 54
APJ Antagonist
MM 54 is a competitive antagonist of the APJ receptor, exhibiting an IC50 value of 93 nM. This compound demonstrates potent and selective inhibition of apelin binding and activation of the apelin receptor (APLNR). MM 54 is suited for research applications focused on elucidating the role of the APJ signaling pathway in various physiological and pathological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1313027-43-8 |
| Applications | APJ Antagonist |
| Formula | C70H121N29O15S4 |
| Molecular Weight | 1737.16 |
| SMILES | O=C1N2[C@@](CCC2)(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CSSC[C@H](NC([C@H](CC3=CN=CN3)NC([C@@H](NC(=O)[C@H]4NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]5(N(C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CSSC4)CCC5)[H])CCCCN)=O)=O)C(=O)N[C@H]1CCCNC(=N)N)[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.