Fig. 1 · Structure
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MMP-9-IN-4
MMP-9 Inhibitor
MMP-9-IN-4 is a highly potent inhibitor of matrix metalloproteinase 9 (MMP-9), exhibiting an IC50 value of 7.46 nM, and it demonstrates strong H-π interactions with the target. Additionally, MMP-9-IN-4 inhibits AKT activity with an IC50 of 8.82 nM, contributing to its biological profile. This compound displays cytotoxic effects and induces apoptosis in various cell lines, making it a valuable reagent in cancer research applications, particularly in studies focused on tumor progression and metastasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2581824-39-5 |
| Applications | MMP-9 Inhibitor |
| Formula | C28H19F3N4O6 |
| Molecular Weight | 564.47 |
| SMILES | O=C(C(N(C1=CC=CC=C1)C(C2=CC=C(C=C2)C(F)(F)F)=O)C3=CC=C(C=C3)[N+]([O-])=O)NC4=CC=C(C=C4)[N+]([O-])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.