Fig. 1 · Structure
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MMP13-IN-2
MMP13 Inhibitor
MMP13-IN-2 is a highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13), with an IC50 value of 0.036 nM. Demonstrating over 1,500-fold selectivity for MMP-13 compared to other MMPs such as MMP-1, 3, 7, 8, 9, 14, and TACE, this compound effectively blocks collagen release from cartilage in vitro. MMP13-IN-2 is valuable for research focusing on collagenase-related diseases and investigating the role of MMP-13 in various pathological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 935759-55-0 |
| Applications | MMP13 Inhibitor |
| Formula | C24H19FN6O4S |
| Molecular Weight | 506.51 |
| SMILES | O=C(C(NC1=C2C(C3=CC=CC(F)=C3)=CS1)=NC2=O)NCC4=CC=CC(OCCOC5=NC=NN5)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.