Fig. 1 · Structure
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MMPI-1154
MMP-2 Inhibitor
MMPI-1154 is an imidazole-carboxylic acid (ICA) compound that serves as a potent inhibitor of matrix metalloproteinase-2 (MMP-2), exhibiting an IC50 value of 6.6 μM. This novel reagent also displays inhibitory effects on MMP-13, MMP-1, and MMP-9, with corresponding IC50 values of 1.8 μM, 10 μM, and 13 μM, respectively. MMPI-1154 is valuable for research applications focused on acute myocardial infarction and other conditions associated with matrix remodeling and cardiovascular protection.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1382722-47-5 |
| Applications | MMP-2 Inhibitor |
| Formula | C26H24FN3O3 |
| Molecular Weight | 445.49 |
| SMILES | O=C(C1=CN=C(CN(CC2=CC=C(F)C=C2)CC3=CC=C(OCC4=CC=CC=C4)C=C3)N1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.