Fig. 1 · Structure
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MMV1557817
Antimalarial
MMV1557817 is a potent antimalarial compound that exhibits selective, nanomolar inhibition of aminopeptidases M1 and M17 in Plasmodium falciparum and Plasmodium vivax. This inhibition disrupts end-stage hemoglobin digestion in asexual parasites, making it a valuable tool for research on malaria pathogenesis and treatment strategies. Its oral bioavailability enhances its potential for in vivo studies and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2065197-82-0 |
| Applications | Antimalarial |
| Formula | C20H21F3N2O3 |
| Molecular Weight | 394.39 |
| SMILES | CC(C)(CC(NC(C1=CC=C(C=C1)C2=CC(F)=C(C(F)=C2)F)C(NO)=O)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.