Mongersen is a targeted SMAD7 antisense oligonucleotide that restores TGF-β1 activity, thereby inhibiting inflammatory pathways. This compound has demonstrated the ability to attenuate experimental colitis resembling Crohn's disease in murine models. Its application is particularly relevant in studying inflammation and fibrosis related to gastrointestinal disorders.
Mongersen is a targeted SMAD7 antisense oligonucleotide that restores TGF-β1 activity, thereby inhibiting inflammatory pathways. This compound has demonstrated the ability to attenuate experimental colitis resembling Crohn's disease in murine models. Its application is particularly relevant in studying inflammation and fibrosis related to gastrointestinal disorders.
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